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Figure 7 | Algorithms for Molecular Biology

Figure 7

From: AlignMiner: a Web-based tool for detection of divergent regions in multiple sequence alignments of conserved sequences

Figure 7

Correlation between the most divergent amino acid sequences and antigenicity of the AtGS1 protein MSA. (A) Similarity plot obtained using the Entropy method; the most divergent regions being are highlighted. (B) Aligned sequences for the two divergent regions together (underlined in black) and their score in relation to other divergent regions. (C) Localisation of each divergent region in the alignment where: (i) nucleotides in bold are the predicted epitopes for B-cells; (ii) an "e" denotes predicted solvent accessibility for this position; and (iii) red-boxed amino acids correspond to the sequence of the matching divergent region. It is clearly seen that divergent sequences overlap with the predicted epitopes and the solvent-accessible amino acids.

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