Fig. 3
From: Implications of non-uniqueness in phylogenetic deconvolution of bulk DNA samples of tumors
Non-uniqueness of solutions in a multi-region lung cancer cohort of 100 patients [18]. a In this lung cancer cohort of 100 patients, 1 to 7 regional samples (y-axis) of each cancer have undergone bulk DNA sequencing, followed by the identification of mutations clusters (x-axis) using PyClone [34]. b This dataset exhibits extensive non-uniqueness of solutions (median of 3 solutions per patient). The number of solutions increased when downsampling the number m of bulk samples (color indicates the number of removed samples)