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Table 1 Average computation time (in minutes) over 5 replicates for varying dimensions of \(\tilde{\mathbf {X}}^{ G }\), with the dimension of \(\tilde{\mathbf {X}}^{ G }\) being fixed (\(N_{ M }=6\))

From: Fast computation of genome-metagenome interaction effects

\(N_{ G }\)

50

100

500

1000

1500

2000

3000

4000

\(\rho \)-SICOMORE

0.01

0.01

0.02

0.03

0.03

0.04

0.05

0.06

SICOMORE

0.21

0.34

0.82

0.76

0.75

0.96

0.93

1.09

MLGL

0.06

0.09

3.35

0.86

3.12

4.52

8.02

24.20

GLtree

0.07

0.28

0.67

3.83

11.69

26.31

88.17

210.64